Drug Release from a Three-Dimensionally Perforated Porous Apatite/Collagen Composite Cement
نویسندگان
چکیده
Artificial bone (PC, containing 3% indomethacin) with biocompatibility, inter-connective pore structure, and drug delivery ability was obtained from self-setting apatite/collagen composite cement. X-ray powder diffraction and FT-IR spectroscopy suggested that PC consisted of carbonated apatite and had a structure similar to that of natural rat bone. The IMC release rates from a PC block containing the drug were measured in simulated body fluid. The rate of release increased with the number of macropore, that from planar surface matrix systems followed the Higuchi equation.
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